SCREEN-CUP Study: Improving Endometrial Cancer Screening in Lynch Syndrome 

Our laboratory is launching a clinical pilot study to evaluate a non-invasive method for detecting endometrial cancer in individuals with Lynch syndrome—a hereditary condition that increases the risk of several cancers, including uterine cancer.

Study Goal

This study investigates whether menstrual cup–based endometrial tissue collection can serve as a more comfortable and accurate alternative to the traditional endometrial biopsy. By comparing the two sample types, we aim to assess the effectiveness of this novel approach for early detection of endometrial cancer.

Tissue Modeling and Research

As part of the study, we will also create endometrial organoids—miniaturized, lab-grown versions of endometrial tissue. These models, developed from patient samples, will be used to study the molecular biology of Lynch syndrome and enhance our understanding of cancer development in this high-risk population.

Long-Term Vision

Our broader goal is to contribute to the development of non-invasive screening tools and support personalized cancer prevention strategies for individuals with inherited cancer risk.

Learn More

If you would like more information about this study—whether as a potential participant or a referring provider—please feel free to contact our research team.

Contact   cediresearch@dfci.harvard.edu